Health Blog


New drug helps limits brain damage and repair

Published on 2017-03-17 07:03:37

When the world is grappling with health hazards, scientist and physicians have been dedicating the valuable time research on various health issues to save humanity for the plight and sorrow. Their dedicated efforts in research and development help inventing new drugs and discovering many medical technologies for incurable the health issues and diseases.

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We know among all the leading causes of death and disability worldwide, stroke is the second leading reason. Stroke occurs when the blood flow to the brain is interrupted or blocked causing destruction to the brain cell due to the deprivation of oxygen and nutrients, which can cause your brain cells to die. There may be two causes of the stroke--- it may be caused by the leaking or bursting of a blood vessel (hemorrhagic stroke) or a blocked artery ischemic stroke). New research results research shows a drug already approved to treat other conditions not only limits stroke damage, but it also promotes repair.

 

An innovative study and research report is published in the journal Brain, Behavior, and Immunity which was led by the researchers in the University of Manchester in the United Kingdom. Stuart Allan, the lead researcher and professor of neuroscience at Manchester, investigated the effect of an anti-inflammatory drug, interleukin-1 receptor antagonist (IL-1Ra), on rats after a stroke. IL-1Ra, which is already a licensed drug for the treatment of rheumatoid arthritis and several early stage clinical trials is being used a stroke treatment. It is found that the rats treated with IL-1Ra drug not only had reduced brain damage in the early stages following a stroke, but also they showed development of numerous of new brain cells (neurogenesis) after several days later. Irrespective of the physical condition of the rats, the results are promising.

The authors note that while stroke itself can also trigger a robust repair response following injury, many of the new cells generated fail to survive or integrate into the circuits that are already there.

 

This drug helps reducing the number of the brain cells destroyed by the stroke and helps repair the decay. This discovery further helps the discovery of the anti – inflammatory drugs. Interlining the receptors antagonist - an new treatment for the stroke. While researching the effect of IL-1Ra on neurogenesis in the rats' brains, they found the drug “not only increases stem cell proliferation, but also significantly enhances neuroblast migration and the number of newly born neurons after cerebral ischemia